Amphetamine-induced depression may be associated with changes in the monoaminergic and glutamatergic systems, the hypothalamic-pituitary-adrenal (HPA) axis, chronic stress, increased inflammation, decreased levels of brain-derived neurotrophic factor (BDNF), and impacts on synaptic function, neuroplasticity, autophagy, and neurogenesis
A confidence interval needs to be computed for each parameter estimate because this allows to obtain a range for the parameter estimate, which gives an indication about the uncertainty of the parameter value taking into account the quantity and variability of the data
The researchers concluded that Although cats receiving supplemental L-carnitine lost weight at a faster weekly rate than control cats during all intervals except week 16, without body composition studies, the con-clusion cannot be made that carnitine facilitated loss of body fat and conserved lean tissue mass 7 Human Research Human trials of supplemental l-carnitine for weight loss are scarce, and show mixed results
Peer-Reviewed Citations Morales ME, Rueda JJ, Lara-Villalba A, Monteagudo E, Ruiz Martinez MA